About Pitt Hopkins Syndrome: Pitt Hopkins Syndrome (PTHS) is a rare, neuro-developmental disorder caused by a mutation of the TCF4 gene on the 18th chromosome. It is characterized by significant developmental delays, problems with motor coordination (ataxia) and balance, breathing abnormalities, and seizures. Most individuals with Pitt Hopkins do not develop functional speech. Pitt Hopkins affects all races and both genders equally. Since the gene that causes Pitt Hopkins was only found in 2007, currently there are approximately 1500 people in the world diagnosed with this syndrome, however we believe there are many more. Learn more at: https://pitthopkins.org.